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WP 2.3 - Application to pathogens

Leader : Tarek Msadek

Workpackage leader: Institut Pasteur, Dr. Tarek Msadek

WP2.3 will validate the general applicability of the theoretical-experimental approaches developped in the model organism B. subtilis through their application to the Gram-positive pathogens Staphylococcus aureus and Bacillus anthracis . Models developed in WP3.2 and based on the “blueprint” provided by the detailed analysis of B. subtilis will be used to devise and conduct a very specific set of experiments ( i.e. characterisation of specific regulons, targeted genetic modifications) that will then be conducted to most efficiently characterize the operation of regulatory networks controlling pathogenesis in these strains. This will involve:

In close collaboration with the Computational Pillar (WP3.1 & WP3.2), WP2.1 and WP2.2 will contribute to establishing a generic strategy of integrated experimental and modelling approaches that will then be applied to Gram-positive pathogens in WP2.3 to validate the generic applicability of the strategy. All the activities described in the Biology Pillar will effectively involve performing experiments required to establish or validate computational methods and models.