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University of Newcastle of Australia (Uni New Aus)

Location : Callaghan / AUS
Leader : N/A
Website :

- Short description of the institution:

Since its establishment in 1965, the University of Newcastle has dared to be different. Problem based

learning, pioneered by Newcastle some 25 years ago, forms the core of its programs in medicine, engineering, architecture, construction management, nursing and law. With Centres of Excellence and highly cited researchers in many disciplines, the University of Newcastle is a dynamic, research intensive university ranked in Australia's Top 10. Close to 26,000 students are enrolled at Newcastle

in undergraduate and postgraduate programs across five faculties as well as a number of enabling programs. Serving a combined regional community of more than 750,000, the University enjoys significant research and teaching partnerships throughout Asia and the Pacific and in Europe, North

America and Africa. The University of Newcastle is committed to equity, ethics, innovation and excellence.

- Description of the different units involved in the project/ Competences of the team in the project:

Competences: Design, development and testing of fluorescent protein fusion plasmid vectors. Development of standard growth conditions for quantitative comparative analysis of fluorescent protein fusion localisation dynamics in situ and quantitation of protein levels under these conditions. Development, testing and use of novel pull-down assays for the quantitative analysis of transcription complex composition and identification of novel transcription factors.

- Key persons involved in BaSysBio:

Dr Peter Lewis

Senior Lecturer School of Environmental and Life Sciences has spent his entire research career involved in aspects of Bacillus subtilis biology. He has substantial experience using GFP, designing and constructing plasmid vectors for the generation of fluorescent protein fusions in Gram positive bacteria, live cell imaging, and the development of imaging techniques. Dr Lewis has worked on aspects of chromosome replication, and was the first to characterise the proteins and sequence elements involved in the termination of chromosome replication. This work has important implications on our understanding of the process of chromosome segregation prior to cell division. He has also worked on the highly asymmetric chromosome segregation involved at the beginning of sporulation, and the control of differential gene expression on the initiation of sporulation showing it is the accumulation of a dephosphorylated form of an anti-anti-factor in the prespore that establishes compartment-specific gene expression during sporulation. More recently he has been working on the subcellular organisation of transcription, how this affects chromosome organisation, and how the localisation of transcription complexes relates to their biological function.

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