|Location : Lyngby / DK|
|Leader : N/A|
|Website : www.dtu.dk/English.aspx|
- Short description of the institution:
The Center for Biological Sequence Analysis has obtained important results from bioinformatics research within the past 13 years. Starting in 1993, we have been able to create one of the largest, multi-disciplinary basic research groups within bioinformatics in academia in Europe. From a quite small activity funded by minor grants in the period 1988-92, the center has grown into a large effort with more than 90 employees, and an established formal group structure in addition to in-house laboratory facilities. CBS has been funded by two five-year grants from the Danish National Research Foundation, in addition to other grants from Danish and Nordic research councils, Wallenberg, EU, NIH and industry. In all grants that CBS have had, the objectives have been met within delivery and cost schedules.
The aim and scope of the work at the center has allowed for a considerable amount of basic research in new methods and approaches. The center works in eight specialist research groups, has a highly multi-disciplinary profile (molecular biologists, biochemists, medical doctors, physicists and computer scientists) with a ratio of 2:1 of bio-to-nonbio backgrounds. The seven different subareas are each headed by a group leader: Systems Biology of Gene Expression (Group leader: Zoltan Szallasi); Protein post-translational modification (Group leader: Nikolaj Blom); Immunological bioinformatics (Group leader: Ole Lund); Molecular evolution (Group leader: Anders Gorm Pedersen); Comparative microbial genomics (Group leader: David Wayne Ussery); Chemoinformatics (Group leader Svava Osk Jonsdottir); and Integrative systems biology (Group leader: Søren Brunak).
Unlike many other groups in the field of biomolecular informatics, the Center for Biological Sequence Analysis directs its research primarily towards topics related to the elucidation of the functional aspects of complex biological mechanisms. Among contemporary bioinformatics concerns are reliable computational interpretation of a wide range of experimental data, and the detailed understanding of the molecular apparatus behind cellular mechanisms of sequence information. By exploiting available experimental data and evidence in the design of algorithms, sequence correlations and other features of biological significance can be inferred.
- Description of the different units involved in the project/ Competences of the team in the project:
In addition to the computational research the center also has experimental efforts in gene expression analysis using DNA chips and data generation in relation to the physical and structural properties of DNA. This work is undertaken by the Systems Biology of Gene Expression group at CBS. In the last decade, the group has produced a large number of computational methods, which are offered to others via WWW servers. The group has worked on several different areas within gene expression studies during the last five years. They have developed a variety of methods dealing with many different aspects within both design of probes for microarrays and analysis of gene expression data.
- Key persons involved in BaSysBio:
Dr. Hanne Jarmer , assistant professor, PhD in Bioinformatics, perl- and R-programming, statistical analysis of microarray data, systems biology, designing of oligos for the use in microarray studies
Dr. Christopher Workmann , assistant professor , PhD in Bioinformatics, assistant professor at CBS, perl- and R-programming, specializes within normalization and clustering of data, systems biology
Dr. Henrik Bjørn Nielsen , assistant professor, PhD in Bioinformatics, assistant professor at CBS, relevant competences: perl- and R-programming, statistical analysis of microarray data, systems biology, oligo design (OligoWiz).
Simon Rasmussen (male), PhD student, Masters in Biotechnology, enrolled as a PhD-student within bioinformatics, perl- and R-programming, analysis of microarray data