|Location : Jouy-en-Josas / F|
|Leader : Philippe Noirot|
|Website : www.inra.fr|
- Short description of the institution:
INRA has built up a portfolio of fundamental scientific knowledge and skills which are principally founded in the life sciences, but also in economic and social sciences, mathematics and applied informatics, environmental sciences and food sciences, etc. The research carried out by INRA is in close interaction with society and is concerned with ensuring the public good. As the leading agricultural research institute in Europe, INRA aims to play a major role in pooling research resources and constructing the European Research Area. In a public-sector, mission-oriented research agency, it is necessary to master and explore recent advances in biology using high throughput approaches and modelling at different scales of the life sciences, so as to be able to make an important and fundamental contribution to improving our understanding of research issues.
- Description of the different units involved in the project:
The laboratory of Microbial Genetics (GM) has a long-standing interest and widely recognised expertise in the field of bacterial DNA metabolism, and is one of the leaders in the field of comparative and functional genomics of Gram-positive bacteria. The group headed by Dr. P. Noirot works in the field of interactomics using the yeast two-hybrid and tandem affinity purification of complexes, and in the functional analysis of chromosome dynamics. The group also has expertise in phage/bacterium interactions in Gram-positive bacterium, and studies the bacteriophage-encoded homologous recombination systems.
The laboratory of Mathematics, Informatics, and Genomes (MIG) has a widely recognised expertise in developing computational methods for genome annotation, detection of genes and motifs, comparative genomics approaches, and transcriptome and proteome analyses. The group led by Dr. P. Bessières has developed several databases (Micado, SPiD), and has conceived integrated databases and interfaces mostly dedicated to the analysis of bacterial genomes. The group led by Dr. V. Fromion has expertise in dynamic modelling and computer simulations of cellular processes.
The laboratory of Microbiology and Molecular Genetics (MGM) has a widely recognised expertise in the field of carbon metabolism, and in the biochemical and structural characterisation of transcriptional regulators. The group led by Dr S. Aymerich studies transcriptional and metabolic regulations, and has discovered two novel key regulators of the central carbon metabolism.
- Key persons involved in BaSysBio:
Dr. Philippe Noirot
(INRA, BaSysBio coordinator, Director of the GM laboratory): Bacterial interactome to explore the functional links between the different cellular processes.
Dr. Stéphane Aymerich
(INRA, Deputy director of the INRA Microbiology department, MGM laboratory), Core carbon metabolism regulatory network
Dr. Philippe Bessières
(INRA, co-founder of the MIG laboratory): Data integration, automated extraction of biological knowledge, and computational biology.
Dr. Elena Bidnenko
(INRA, GM laboratory): phage/bacterium interactions, and phage-encoded homologous recombination systems.
Dr. Vincent Fromion
(INRA, MIG laboratory ): Computational modelling of metabolic pathways, and control logic.